1-溴-3-甲基-2-丁烯合成路线 （共 689 条）
反应条件
potassium hydroxide in water
T=0°C;
参考文献
Crombie; Jones; Palmer
Tetrahedron Letters, 1985 , vol. 26, # 24 p. 2929 - 2932
反应条件
in N,N-dimethyl-formamide
T=25°C; 48 h;
参考文献
Couladouros, Elias A.; Strongilos, Alexandros T.; Papageorgiou, Vassilios P.; Plyta, Zoi F.
Chemistry - A European Journal, 2002 , vol. 8, # 8 p. 1795 - 1803
反应条件
in N,N-dimethyl-formamide
参考文献
Bordwell,F.G.; Mecca,T.G.
Journal of the American Chemical Society, 1972 , vol. 94, # 16 p. 5829 - 5837
参考文献
Pala,G. et al.
Journal of Medicinal Chemistry, 1970 , vol. 13, # 3 p. 556 - 557
反应条件
aluminum oxide in diethyl ether; hexane
120 h;
参考文献
Gluesenkamp, Karl-Heinz; Buechi, George
Journal of Organic Chemistry, 1986 , vol. 51, # 23 p. 4481 - 4483
反应条件
sodium carbonate; zinc(II) chloride in water; pentane; benzene
参考文献
Cornell Research Foundation, Inc.
Patent: US4656189 A1, 1987 ;
反应条件
tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate in toluene
T=110°C; Suzuki-Miyaura coupling; 17 h; Inert atmosphere;
参考文献
Gerbino, Dario C.; Mandolesi, Sandra D.; Schmalz, Hans-Guenther; Podesta, Julio C.
European Journal of Organic Chemistry, 2009 , # 23 p. 3964 - 3972
反应条件
palladium diacetate in 1,4-dioxane
T=100°C; Suzuki-Miyaura coupling; 12 h;
参考文献
Gerbino, Dario C.; Mandolesi, Sandra D.; Schmalz, Hans-Guenther; Podesta, Julio C.
European Journal of Organic Chemistry, 2009 , # 23 p. 3964 - 3972
反应条件
Pd-PEPPSI-IPent; potassium hydroxide in tetrahydrofuran
T=70°C; Suzuki-Miyaura Coupling; 24 h; Inert atmosphere; regioselective reaction;
参考文献
Farmer, Jennifer L.; Hunter, Howard N.; Organ, Michael G.
Journal of the American Chemical Society, 2012 , vol. 134, # 42 p. 17470 - 17473
反应条件
1.1: potassium carbonate / acetone / Reflux
2.1: sodium hydride / dichloromethane / 0.33 h / Inert atmosphere
2.2: 2 h
3.1: copper(l) iodide / tetrahydrofuran / 1 h / 70 °C / Inert atmosphere
View Scheme
参考文献
Li, Man-Bo; Tang, Xiang-Ling; Tian, Shi-Kai
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 11-12 p. 1980 - 1984
