1-溴-3-甲基-2-丁烯合成路线 （共 689 条）
反应条件
sodium hydride in toluene
T=35°C; 24 h;
参考文献
Wang, Yang; Wu, Jiang; Xia, Peng
Synthetic Communications, 2006 , vol. 36, # 18 p. 2685 - 2698
反应条件
1: (i) OH-, (ii) /BRN= 1420778/
2: SnCl4
3: (i) NaH, ClPO(OEt)2, (ii) /BRN= 3556005/
4: (i) LiAlH4, (ii) aq. HBr
View Scheme
参考文献
Sum,F.W.; Weiler,L.
Journal of the American Chemical Society, 1979 , vol. 101, p. 4401 - 4403
反应条件
1: 11 percent / K2CO3 / methanol / 10 h / Ambient temperature
2: 32 percent / Dowex 50 / methanol / 24 h / 40 °C
View Scheme
参考文献
Fukai, Toshio; Nomura, Taro
Heterocycles, 1992 , vol. 34, # 6 p. 1213 - 1225
反应条件
tetrabutylammonium dibromocuprate(I); lithium
1.) ethyl ether, -15 deg C, 2 h, 2.) ethyl ether, -70 deg C; Yield given. Multistep reaction;
参考文献
Baeckstroem, Peter; Bjoerkling, Fredrik; Hoegberg, Hans-Erik; Norin, Torbjoern
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1984 , vol. 38, # 9 p. 779 - 782
反应条件
lithium bromide
T=-25°C; Title compound not separated from byproducts.;
参考文献
Ciszewski, James T.; Xie, Baohan; Cao, Changsheng; Odom, Aaron L.
Dalton Transactions, 2003 , # 22 p. 4226 - 4227
反应条件
Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Zhu, Lishan; Wehmeyer, Richard M.; Rieke, Reuben D.
Journal of Organic Chemistry, 1991 , vol. 56, # 4 p. 1445 - 1453
反应条件
potassium carbonate in acetone
1 h; Heating;
参考文献
Khan, Saeed Ahmad; Krishnamurti, M.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 3 p. 276 - 277
反应条件
triethylamine; sodium iodide in dimethyl sulfoxide
T=20 - 45°C;
参考文献
Yang, Rui-Yang; Kizer, Darin; Wu, Hui; Volckova, Erika; Miao, Xiu-Sheng; Ali, Syed M.; Tandon, Manish; Savage, Ronald E.; Chan, Thomas C.K.; Ashwell, Mark A.
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 10 p. 5635 - 5643
反应条件
1: 1) LDA / 1) THF, -78 deg C, 15 min., 2) RT, 1h
2: 83 percent / tetrahydrofuran / 1) -70 deg C, 10 min, 2) RT, 1h
3: 61 percent / 2M HCl / methanol / 1 h / Ambient temperature
4: 70 percent / 6M H2SO4 / methanol / 1 h / Heating
View Scheme
参考文献
Okazaki, Renji; Negishi, Yoshio; Inamoto, Naoki
Journal of Organic Chemistry, 1984 , vol. 49, # 20 p. 3819 - 3824
反应条件
Montmorillonite K10 in tetrachloromethane
T=20°C; 16 h;
参考文献
Li, Fu-Nan; Kim, Nam-Jung; Paek, Seung-Mann; Kwon, Do-Yeon; Min, Kyung Hoon; Jeong, Yeon-Su; Kim, Sun-Young; Park, Young-Ho; Kim, Hee-Doo; Park, Hyeung-Geun; Suh, Young-Ger
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 10 p. 3557 - 3567
