1-溴-3-甲基-2-丁烯合成路线 （共 689 条）
反应条件
sodium hydroxide; tetraphenyl arsonium chloride
T=40°C; 4 h; Title compound not separated from byproducts;
参考文献
Dehmlow, Eckehard V.; Wilkenloh, Juergen
Liebigs Annalen der Chemie, 1990 , # 2 p. 125 - 128
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride
参考文献
Baird,M.S. et al.
Journal of the Chemical Society, Chemical Communications, 1979 , p. 210 - 211
反应条件
potassium carbonate in N,N-dimethyl-formamide
6 h;
参考文献
Orsini; Verotta; Lecchi; Restano; Curia; Redaelli; Wanke
Journal of Natural Products, 2004 , vol. 67, # 3 p. 421 - 426
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / 0 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: hydrogenchloride; water / methanol / 10 h / 20 °C / Inert atmosphere
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Park, Byung Ho; Lee, Hee Jin; Lee, Yong Rok
Journal of Natural Products, 2011 , vol. 74, # 4 p. 644 - 649
反应条件
magnesium in diethyl ether
参考文献
Apparu, Marcel; Barrelle, Michel
Bulletin de la Societe Chimique de France, 1983 , vol. 2, # 3-4 p. 83 - 86
反应条件
1.1: n-butyllithium / tetrahydrofuran; cyclohexane / 0.5 h / 0 °C
1.2: 86 percent / tetrahydrofuran; cyclohexane / 0.5 h
2.1: potassium bis(trimethylsilyl)amide / tetrahydrofuran; toluene / -78 °C
2.2: 82 percent / tetrahydrofuran; toluene / -78 - 20 °C
3.1: 75 percent / CuCN / diethyl ether / 2.5 h / -78 °C
4.1: 83 percent / diisobutylaluminum hydride / toluene / 1 h / -78 °C
View Scheme
参考文献
Rawat, Diwan S; Gibbs, Richard A
Organic letters, 2002 , vol. 4, # 18 p. 3027 - 3030
反应条件
1: 80 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 1 h / -78 deg C -> -10 deg C
2: 81 percent / LiAlH4 / diethyl ether
3: 94 percent / pyridine / 1 h / 0 °C
View Scheme
参考文献
Corey, E. J.; Hashimoto, Shun-ichi; Barton, Alan E.
Journal of the American Chemical Society, 1981 , vol. 103, # 3 p. 721 - 722
反应条件
magnesium; 3-chloro-benzenecarboperoxoic acid
1.) ether; 2.); Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Apparu, Marcel; Barrelle, Michel
Bulletin de la Societe Chimique de France, 1983 , vol. 2, # 3-4 p. 83 - 86
反应条件
1: diethyl ether
2: hydrogen chloride / anschliessend mit wss. Salzsaeure
View Scheme
参考文献
Lewina et al.
Zhurnal Obshchei Khimii, 1959 , vol. 29, p. 2236,2237;engl.Ausg.S.2202,2204
反应条件
1: diethyl ether
2: nickel / Hydrogenation
View Scheme
参考文献
Lewina et al.
Zhurnal Obshchei Khimii, 1959 , vol. 29, p. 2945,2948,2949;engl.Ausg.S.2906,2909,2910
