1-溴-3-甲基-2-丁烯合成路线 （共 689 条）
反应条件
potassium carbonate in acetone
T=20°C;
参考文献
He, Jianghua; Li, Jizhen; Liu, Zai-Qun
Medicinal Chemistry Research, 2013 , vol. 22, # 6 p. 2847 - 2854
反应条件
sodium dihydrogenphosphate
12 h; Heating;
参考文献
Yoon,U.C.; Quillen,S.L.; Mariano,P.S.
Journal of the American Chemical Society, 1983 , vol. 105, p. 1204
参考文献
Johnston, Blair D.; Czyzewska, Eva; Oehlschlager, Allan C.
Journal of Organic Chemistry, 1987 , vol. 52, # 16 p. 3693 - 3697
反应条件
sodium isopropanolate in isopropyl alcohol
Heating;
参考文献
Caliendo, Giuseppe; Santagada, Vincenzo; Perissutti, Elisa; Severino, Beatrice; Fiorino, Ferdinando; Warner, Timothy D; Wallace, John L; Ifa, Demian Rocha; Antunes, Edson; Cirino, Giuseppe; De Nucci, Gilberto
European Journal of Medicinal Chemistry, 2001 , vol. 36, # 6 p. 517 - 530
反应条件
potassium hydroxide
T=20°C; 16 h;
参考文献
Helesbeux, Jean-Jacques; Duval, Olivier; Dartiguelongue, Caroline; Seraphin, Denis; Oger, Jean-Michel; Richomme, Pascal
Tetrahedron, 2004 , vol. 60, # 10 p. 2293 - 2300
反应条件
1: (3S,4S,5S)-3-Butyl-5-methyl-4-triisopropylsilanyloxy-dihydro-furan-2-one With cesium hydroxide in water; tert-butyl alcohol
T=0°C; Hydrolysis;
2: prenyl bromide With pyridine in diethyl ether
T=0°C; Esterification; 24 h;
参考文献
Tsunoda; Nishii; Yoshizuka; Yamasaki; Suzuki; Ito
Tetrahedron Letters, 2000 , vol. 41, # 40 p. 7667 - 7671
反应条件
Multistep reaction.;
参考文献
Maiti, Arup; Cuendet, Muriel; Croy, Vicki L.; Endringer, Denise C.; Pezzuto, John M.; Cushman, Mark
Journal of Medicinal Chemistry, 2007 , vol. 50, # 12 p. 2799 - 2806
反应条件
1.1: Na / diethyl ether
1.2: 74 percent / ZnBr2 / CH2Cl2
2.1: 93 percent / K2CO3 / acetone / Heating
3.1: 85 percent / t-BuLi / tetrahydrofuran / -78 °C
View Scheme
参考文献
Li, Yuan-Qiang; Sugase, Kenji; Ishiguro, Masaji
Tetrahedron Letters, 1999 , vol. 40, # 51 p. 9097 - 9100
反应条件
potassium carbonate in acetone
8 h; Heating;
参考文献
Dubery, Ian A.; Louw, Anna E.; Van Heerden, Fanie R.
Phytochemistry, 1999 , vol. 50, # 6 p. 983 - 989
反应条件
1: salicylaldehyde With sodium hydride in N,N-dimethyl-formamide
T=0°C; 0.333333 h;
2: prenyl bromide in N,N-dimethyl-formamide
T=0 - 20°C; 12 h;
参考文献
Lee, Yong Rok; Kim, Yun Mi; Kim, Sung Hong
Tetrahedron, 2009 , vol. 65, # 1 p. 101 - 108
