1: With sodium tetrahydroborate in tetrahydrofuran; hexane; water T=0°C; 0.0833333 h; 2: With hydrogenchloride in tetrahydrofuran; hexane; water T=0 - 40°C; 2 h; 3: With sodium hydroxide in tetrahydrofuran; hexane; water T=0 - 15°C; pH=12;
1: With sodium tetrahydroborate; calcium chloride in tetrahydrofuran; methanol T=-20 - 20°C; 2: With ammonium chloride in tetrahydrofuran; ethanol; water
参考文献
ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.
Patent: WO2007/87135 A2, 2007 ;
Location in patent: Page/Page column 66 ;
WO 2007/087135 A2