2-(三氟甲基)吡啶-3-甲腈合成路线 （共 5 条）
反应条件
ammonia in methanol; water T=60°C; 3.5 h;
参考文献
BIAL - PORTELA and CA., S.A.
Patent: WO2009/54742 A2, 2009 ;
Location in patent: Page/Page column 14 ;
反应条件
triethylamine; trifluoroacetic anhydride in dichloromethane T=20°C; 4 h;
参考文献
EP2361902 A1, ;
Page/Page column 40 ;
EP 2361902 A1
反应条件
trifluoroacetic anhydride in monofluorodichloromethane
T=0 - 5°C; 16.3 h;
参考文献
BIAL - PORTELA and CA., S.A.
Patent: WO2009/54742 A2, 2009 ;
Location in patent: Page/Page column 14-15 ;
反应条件
trifluoroacetic anhydride in monofluorodichloromethane
T=0 - 5°C; 16.3 h;
参考文献
BIAL - PORTELA and CA., S.A.
Patent: WO2009/54742 A2, 2009 ;
Location in patent: Page/Page column 14-15 ;
反应条件
urea hydrogen peroxide addition compound; trifluoroacetic anhydride in dichloromethane
T=20°C; Inert atmosphereCooling;
参考文献
Kiss, Laszlo E.; Ferreira, Humberto S.; Torrao, Leonel; Bonifacio, Maria Joao; Palma, P. Nuno; Soares-Da-Silva, Patricio; Learmonth, David A.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 8 p. 3396 - 3411
