2-氟-5-甲氧基-4-甲基苯甲酸合成路线 (共 2 条)
反应条件
1: 2-fluoro-5-methoxybenzoic acid With potassium tert-butylate in tetrahydrofuran; hexane
T=-78°C; 0.666667 h;
2: methyl iodide in tetrahydrofuran; hexane
T=-78 - 20°C; 1.16667 h;
3: With ammonium chloride in tetrahydrofuran; hexane; water
Saturated solution;
参考文献
AMGEN INC.
Patent: WO2005/113494 A2, 2005 ;
Location in patent: Page/Page column 119-120 ;
WO 2005/113494 A2
反应条件
water; hydrogen bromide; acetic acid
T=140°C;
参考文献
AMGEN INC.
Patent: WO2005/113494 A2, 2005 ;
Location in patent: Page/Page column 120 ;
WO 2005/113494 A2