3,5-二氟吡啶-4-甲醛合成路线 （共 6 条）
反应条件
1: 3,5-difluoropyridine With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-70°C; 0.5 h; Inert atmosphere; 2: formic acid methyl ester in tetrahydrofuran; hexane T=-70°C; 1.5 h;
参考文献
BAYER PHARMA AKTIENGESELLSCHAFT; VAKALOPOULOS, Alexandros; HARTUNG, Ingo; FOLLMANN, Markus; JAUTELAT, Rolf; STRAUB, Alexander; HAßFELD, Jorma; LINDNER, Niels; SCHNEIDER, Dirk; WUNDER, Frank; STASCH, Johannes-Peter; REDLICH, Gorden; LI, Volkhart Min-Jian; BECKER-PELSTER, Eva Maria; KNORR, Andreas
Patent: US2014/128386 A1, 2014 ;
Location in patent: Paragraph 1410; 1411; 1412; 1413; 1414 ;
反应条件
lithium hexamethyldisilazane in tetrahydrofuran T=-30 - -15°C; 1 h; Industry scale;
参考文献
WO2012/51450 A1, ;
Page/Page column 19 ;
WO 2012/051450 A1
反应条件
hydrogenchloride 2 h; Heating;
参考文献
Ko, Yoon-Joo; Park, Kyung-Bae; Shim, Seung-Bo; Shin, Jung-Hyu
Journal of Fluorine Chemistry, 2006 , vol. 127, # 6 p. 755 - 759
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 10 p. 2789 - 2794
反应条件
1: NFSi 2: conc. HCl View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 10 p. 2789 - 2794
反应条件
1: NFSi 2: conc. HCl View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 10 p. 2789 - 2794
