2-异丙氧基吡啶-5-硼酸合成路线 (共 2 条)
反应条件
1: 5-bromo-2-isopropoxy-pyridine With n-butyllithium in diethyl ether; hexane T=-78°C; 2 h; 2: tri-isopropoxy-borane in diethyl ether; hexane T=-78 - 20°C; 2 h; 3: With water in diethyl ether; hexane T=20°C;
参考文献
WO2005/116000 A1, ;
Page/Page column 52-53 ;
WO 2005/116000 A1
反应条件
1: With n-butyllithium in diethyl ether; hexane T=-78°C; 2 h; Inert atmosphere; 2: With tri-isopropoxy-borane in diethyl ether; hexane T=-78°C; 2 h; Inert atmosphere;
参考文献
Journal of Medicinal Chemistry, , vol. 53, # 1 p. 77 - 105