1: 65 percent / triphenylphosphine / palladium acetate / tetrahydrofuran / 5 h / Heating 2: 95 percent / sodium hydride / diethyl ether / 0 °C 3: 70 percent / diethyl ether / -10 °C 4: 90 percent / triphenylphosphine, carbon tetrachloride / 12 h / Heating 5: diisobutylaluminium hydride / tetrahydrofuran / -40 °C 6: manganese dioxide / hexane / Ambient temperature 7: KCN, 18-crown-6 / 1 h / 0 °C 8: trimethylbenzylammonium fluoride / tetrahydrofuran; H2O / 0 °C 10: 79 percent / sodium bis(trimethylsilyl)amide / tetrahydrofuran / 0.5 h / 56 °C 11: p-toluenesulfonic acid / methanol / 1 h / 0 °C 12: 2percent aqueous sodium hydroxide / diethyl ether / 0.33 h View Scheme