1: 2-((1S,2S,4R)bicyclo[2.2.1]heptan-2-ylamino)-5-methylthiazol-4(5H)-one With n-butyllithium; N,N,N',N,-tetramethylethylenediamine; (R,R)-N,N'-di-(1-phenyl-2-(1-piperidinyl)ethyl)-1,3-propanediamine in toluene T=-15 - 22°C; 1.25 h; 2: 2-iodo-propane in toluene T=-15 - -12.5°C; 0.333333 h;

1: 2-((1S,2S,4R)bicyclo[2.2.1]heptan-2-ylamino)-5-methylthiazol-4(5H)-one With n-butyllithium; N,N,N',N,-tetramethylethylenediamine; (R,R)-N,N'-di-(1-phenyl-2-(1-piperidinyl)ethyl)-1,3-propanediamine in toluene T=-15 - 22°C; Inert atmosphere; 2: 2-iodo-propane in toluene T=-15 - -12.5°C; Inert atmosphere; 3: With water; ammonium chloride in toluene T=20°C;