4-[4’-(三氟甲氧基)苯氧基甲基]苯基硼酸合成路线 （共 3 条）
反应条件
1: With n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran; hexane
T=-78°C; 3.17 h;
2: With hydrogenchloride; water in tetrahydrofuran; hexane
T=-78 - 20°C;
参考文献
Cross, R. Matthew; Maignan, Jordany R.; Mutka, Tina S.; Luong, Lisa; Sargent, Justin; Kyle, Dennis E.; Manetsch, Roman
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4399 - 4426
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C
1.2: 80 °C
2.1: n-butyllithium; tri-isopropoxy-borane / tetrahydrofuran; hexane / 3.17 h / -78 °C
2.2: -78 - 20 °C
View Scheme
参考文献
Cross, R. Matthew; Maignan, Jordany R.; Mutka, Tina S.; Luong, Lisa; Sargent, Justin; Kyle, Dennis E.; Manetsch, Roman
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4399 - 4426
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C
1.2: 80 °C
2.1: n-butyllithium; tri-isopropoxy-borane / tetrahydrofuran; hexane / 3.17 h / -78 °C
2.2: -78 - 20 °C
View Scheme
参考文献
Cross, R. Matthew; Maignan, Jordany R.; Mutka, Tina S.; Luong, Lisa; Sargent, Justin; Kyle, Dennis E.; Manetsch, Roman
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4399 - 4426
