4-氨基-3-羟基苯甲酸乙酯合成路线 （共 7 条）
反应条件
1: With sodium hydrogencarbonate in water; ethyl acetate Cooling with ice; 2: in N,N-dimethyl-formamide T=120°C; P=7500.75 Torr; 0.583333 h; Microwave irradiation;
参考文献
Ilas, Janez; Kikelj, Danijel
Helvetica Chimica Acta, 2008 , vol. 91, # 4 p. 654 - 664
反应条件
potassium fluoride in N,N-dimethyl-formamide T=60°C; 6 h;
参考文献
Zidar, Nace; Kikelj, Danijel
Tetrahedron, 2008 , vol. 64, # 24 p. 5756 - 5761
反应条件
hydrogen; palladium on activated charcoal in ethanol
T=20°C;
参考文献
UNIVERSITY OF LJUBLJANA; LEK PHARMACEUTICALS d.d.
Patent: WO2005/51934 A1, 2005 ;
Location in patent: Page/Page column 44-45 ;
反应条件
1: 96 percent / sulphuric acid / 2 h / Heating
2: 100 percent / H2 / Pd/C / ethanol / 20 °C
View Scheme
参考文献
Anderluh, Petra Stefanic; Anderluh, Marko; Ilas, Janez; Mravljak, Janez; Dolenc, Marija Sollner; Stegnar, Mojca; Kikelj, Danijel
Journal of Medicinal Chemistry, 2005 , vol. 48, # 9 p. 3110 - 3113
参考文献
Einhorn; Pfyl
Justus Liebigs Annalen der Chemie, 1900 , vol. 311, p. 55
Full Text Show Details
Einhorn
Patent: DE97335 ;
反应条件
dicyclohexyl-carbodiimide in tetrahydrofuran
T=20°C; 4 h;
参考文献
Papachristou, Maria; Pirmettis, Ioannis; Siatra-Papastaikoudi, Theodora; Pelecanou, Maria; Tsoukalas, Charalambos; Raptopoulou, Catherine P.; Terzis, Aris; Chiotellis, Efstratios; Papadopoulos, Minas
European Journal of Inorganic Chemistry, 2003 , # 20 p. 3826 - 3830
反应条件
1: 60 percent / triethylamine / diethyl ether / 5 h / -10 - 20 °C
2: 83 percent / aq. NaHCO3 / 1 h / Heating
View Scheme
参考文献
Anderluh, Petra Stefanic; Anderluh, Marko; Ilas, Janez; Mravljak, Janez; Dolenc, Marija Sollner; Stegnar, Mojca; Kikelj, Danijel
Journal of Medicinal Chemistry, 2005 , vol. 48, # 9 p. 3110 - 3113
