[(R)-4-(二甲基氨基)-1-羟基-4-氧代丁烷-2-基]氨基甲酸苄酯合成路线 （共 8 条）
反应条件
1.1: tributylphosphine / toluene / 8 h / 80 °C 2.1: hydrogen bromide; acetic acid / 16 h / 18 - 25 °C 2.2: pH ~ 8 - 9 3.1: borane-THF / tetrahydrofuran / 18 - 25 °C 3.2: 0 °C 3.3: 4 h / Reflux 4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 - 25 °C View Scheme
参考文献
ASTRAZENECA AB
Patent: US2012/35134 A1, 2012 ;
反应条件
tributylphosphine in toluene T=80°C; 16 h;
参考文献
Elmore, Steven W.; Bruncko, Milan; Park, Cheol-Min
Patent: US2005/272744 A1, 2005 ;
Location in patent: Page/Page column 11-12 ;
US 20050272744 A1
反应条件
in tetrahydrofuran
T=20°C; 16 h;
参考文献
Elmore, Steven W.; Bruncko, Milan; Park, Cheol-Min
Patent: US2005/272744 A1, 2005 ;
Location in patent: Page/Page column 11 ;
US 20050272744 A1
反应条件
in tetrahydrofuran
T=20°C; 16 h;
参考文献
ABBOTT LABORATORIES
Patent: US2010/184766 A1, 2010 ;
Location in patent: Page/Page column 42 ;
反应条件
1.1: sodium tetrahydroborate / tetrahydrofuran / 6 h / 0 - 25 °C
1.2: 0 °C / pH 4
2.1: toluene-4-sulfonic acid / toluene / 3 h / Dean-Stark conditions; Reflux
3.1: tetrahydrofuran / 14 h / 18 - 25 °C
View Scheme
参考文献
ASTRAZENECA AB
Patent: US2012/35134 A1, 2012 ;
反应条件
1: toluene-4-sulfonic acid / toluene / 3 h / Dean-Stark conditions; Reflux
2: tetrahydrofuran / 14 h / 18 - 25 °C
View Scheme
参考文献
ASTRAZENECA AB
Patent: US2012/35134 A1, 2012 ;
反应条件
1.1: acetic anhydride / 18 - 25 °C
2.1: sodium tetrahydroborate / tetrahydrofuran / 6 h / 0 - 25 °C
2.2: 0 °C / pH 4
3.1: toluene-4-sulfonic acid / toluene / 3 h / Dean-Stark conditions; Reflux
4.1: tetrahydrofuran / 14 h / 18 - 25 °C
View Scheme
参考文献
ASTRAZENECA AB
Patent: US2012/35134 A1, 2012 ;
反应条件
1.1: tributylphosphine / toluene / 8 h / 80 °C
2.1: hydrogen bromide; acetic acid / 16 h / 18 - 25 °C
2.2: pH ~ 8 - 9
View Scheme
参考文献
ASTRAZENECA AB
Patent: US2012/35134 A1, 2012 ;
