(R)-3-氨基-N,N-二甲基-4-(苯硫基)丁酰胺合成路线 (共 3 条)
反应条件
1.1: borane-THF / tetrahydrofuran / 18 - 25 °C 1.2: 0 °C 1.3: 4 h / Reflux 2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 - 25 °C View Scheme
参考文献
ASTRAZENECA AB
Patent: US2012/35134 A1, 2012 ;
反应条件
hydrogen bromide; acetic acid
T=20°C;
参考文献
Elmore, Steven W.; Bruncko, Milan; Park, Cheol-Min
Patent: US2005/272744 A1, 2005 ;
Location in patent: Page/Page column 12 ;
US 20050272744 A1
反应条件
1.1: tributylphosphine / toluene / 8 h / 80 °C
2.1: hydrogen bromide; acetic acid / 16 h / 18 - 25 °C
2.2: pH ~ 8 - 9
View Scheme
参考文献
ASTRAZENECA AB
Patent: US2012/35134 A1, 2012 ;