(1R)-1-(羟基甲基)-3-(4-吗啉)-3-氧代丙基氨基甲酸苄酯合成路线 （共 6 条）
反应条件
1.1: tributylphosphine / toluene / 80 °C / Inert atmosphere 2.1: hydrogen bromide; acetic acid / 50 h / 18 - 25 °C 2.2: pH ~ 8 - 9 View Scheme
参考文献
ASTRAZENECA AB
Patent: US2012/35134 A1, 2012 ;
反应条件
in 1,4-dioxane
T=70°C; 18 h;
参考文献
Elmore, Steven W.; Bruncko, Milan; Park, Cheol-Min
Patent: US2005/272744 A1, 2005 ;
Location in patent: Page/Page column 20 ;
US 20050272744 A1
反应条件
1.1: sodium tetrahydroborate / tetrahydrofuran / 6 h / 0 - 25 °C
1.2: 0 °C / pH 4
2.1: toluene-4-sulfonic acid / toluene / 3 h / Dean-Stark conditions; Reflux
3.1: tetrahydrofuran / 18 - 25 °C
View Scheme
参考文献
ASTRAZENECA AB
Patent: US2012/35134 A1, 2012 ;
反应条件
1: toluene-4-sulfonic acid / toluene / 3 h / Dean-Stark conditions; Reflux
2: tetrahydrofuran / 18 - 25 °C
View Scheme
参考文献
ASTRAZENECA AB
Patent: US2012/35134 A1, 2012 ;
反应条件
1.1: acetic anhydride / 18 - 25 °C
2.1: sodium tetrahydroborate / tetrahydrofuran / 6 h / 0 - 25 °C
2.2: 0 °C / pH 4
3.1: toluene-4-sulfonic acid / toluene / 3 h / Dean-Stark conditions; Reflux
4.1: tetrahydrofuran / 18 - 25 °C
View Scheme
参考文献
ASTRAZENECA AB
Patent: US2012/35134 A1, 2012 ;
反应条件
tributylphosphine in toluene
T=80°C; 24 h;
参考文献
Elmore, Steven W.; Bruncko, Milan; Park, Cheol-Min
Patent: US2005/272744 A1, 2005 ;
Location in patent: Page/Page column 20 ;
US 20050272744 A1
