4-(1H-咪唑-1-基)-3-甲氧基苯甲醛合成路线 （共 6 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=80°C;
参考文献
Eisai RandD Management Co., Ltd.
Patent: EP2019093 A1, 2009 ;
Location in patent: Page/Page column 45 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=130°C;
参考文献
Eisai Co., Ltd.
Patent: US2006/4013 A1, 2006 ;
Location in patent: Page/Page column 77 ;
US 20060004013 A1
反应条件
oxalyl dichloride in dichloromethane; dimethyl sulfoxide
T=-60°C; 5 h; Inert atmosphere;
参考文献
Zhang, Qin; Zhong, Ying; Yan, Lin-Na; Sun, Xun; Gong, Tao; Zhang, Zhi-Rong
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 3 p. 1010 - 1014
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
2: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 5 h / -60 °C / Inert atmosphere
View Scheme
参考文献
Zhang, Qin; Zhong, Ying; Yan, Lin-Na; Sun, Xun; Gong, Tao; Zhang, Zhi-Rong
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 3 p. 1010 - 1014
反应条件
1: copper(l) iodide / 100 - 110 °C / Inert atmosphere
2: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
3: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 5 h / -60 °C / Inert atmosphere
View Scheme
参考文献
Zhang, Qin; Zhong, Ying; Yan, Lin-Na; Sun, Xun; Gong, Tao; Zhang, Zhi-Rong
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 3 p. 1010 - 1014
反应条件
1: sulfuric acid; potassium iodide; sodium nitrite / water / 1.5 h / -5 °C
2: copper(l) iodide / 100 - 110 °C / Inert atmosphere
3: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
4: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 5 h / -60 °C / Inert atmosphere
View Scheme
参考文献
Zhang, Qin; Zhong, Ying; Yan, Lin-Na; Sun, Xun; Gong, Tao; Zhang, Zhi-Rong
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 3 p. 1010 - 1014
