2-(2,3-二氢-苯并[1,4]二噁英-2-基)-乙胺合成路线 （共 4 条）
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in methanol
T=20°C; Catalytic hydrogenation; P=760 Torr;
参考文献
Sanchez, Isabel; Dolors Pujol, Maria; Guillaumet, Gerald; Massingham, Roy; Monteil, Andre; Dureng, Georges; Winslow, Eileen
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 7-8 p. 663 - 676
反应条件
1: 60 percent / dimethylsulfoxide / 72 h / 65 °C
2: 92 percent / H2; conc. HCl / 10 percent Pd-C / methanol / 20 °C / 760 Torr
View Scheme
参考文献
Sanchez, Isabel; Dolors Pujol, Maria; Guillaumet, Gerald; Massingham, Roy; Monteil, Andre; Dureng, Georges; Winslow, Eileen
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 7-8 p. 663 - 676
反应条件
1: 98 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 20 °C
2: 96 percent / NBS; PPh3 / dimethylformamide / 6 h / 40 °C
3: 60 percent / dimethylsulfoxide / 72 h / 65 °C
4: 92 percent / H2; conc. HCl / 10 percent Pd-C / methanol / 20 °C / 760 Torr
View Scheme
参考文献
Sanchez, Isabel; Dolors Pujol, Maria; Guillaumet, Gerald; Massingham, Roy; Monteil, Andre; Dureng, Georges; Winslow, Eileen
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 7-8 p. 663 - 676
反应条件
1: 96 percent / NBS; PPh3 / dimethylformamide / 6 h / 40 °C
2: 60 percent / dimethylsulfoxide / 72 h / 65 °C
3: 92 percent / H2; conc. HCl / 10 percent Pd-C / methanol / 20 °C / 760 Torr
View Scheme
参考文献
Sanchez, Isabel; Dolors Pujol, Maria; Guillaumet, Gerald; Massingham, Roy; Monteil, Andre; Dureng, Georges; Winslow, Eileen
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 7-8 p. 663 - 676
