3-氨基-5-溴-2-吡啶羧酸合成路线 （共 3 条）
反应条件
1: With sodium hydroxide in water 5 h; Reflux; 2: With hydrogenchloride T=0°C; pH=7;
参考文献
Endo Pharmaceuticals Inc.; Smith, Roger Astbury; Venkatesan, Aranapakam; Bejugam, Mallesham; Hoshalli, Subramanya; Nanduri, Srinivas
Patent: US2014/38952 A1, 2014 ;
Location in patent: Page/Page column 0180-0181 ;
反应条件
1.1: 3-amino-5-bromopyridine-2-carboxylic acid / Raney Nickel / ethanol / 14 h / 20 °C 2.1: sodium hydroxide / water / 5 h / Reflux 2.2: 0 °C / pH 7 View Scheme
反应条件
1: 2.5 h / 200 °C 2: trichlorophosphate; N-ethyl-N,N-diisopropylamine / 10 h / 130 °C View Scheme
参考文献
Endo Pharmaceuticals Inc.; Smith, Roger Astbury; Venkatesan, Aranapakam; Bejugam, Mallesham; Hoshalli, Subramanya; Nanduri, Srinivas
Patent: US2014/38952 A1, 2014 ;
