7-(溴甲基)噻吩并[3,2-d]嘧啶合成路线 （共 4 条）
反应条件
1.1: potassium iodide / N,N-dimethyl-formamide / 1 h / 40 °C 1.2: 15 h / 40 °C 2.1: water; sodium hydroxide / tetrahydrofuran / 2 h / 20 °C 3.1: manganese(IV) oxide / dichloromethane / 2 h View Scheme
参考文献
HANMI PHARM CO., LTD.; BAE, In Hwan; SON, Jung Beom; HAN, Sang Mi; KWAK, Eun Joo; KIM, Ho Seok; SONG, Ji Young; BYUN, Eun Young; JUN, Seung Ah; AHN, Young Gil; SUH, Kwee Hyun
Patent: WO2013/100632 A1, 2013 ;
反应条件
1: trichlorophosphate / N,N-dimethyl-formamide / 4 h / 110 °C
2: palladium(II) oxide hydrate; triethylamine; hydrogen / methanol / 5 h
3: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / benzene / 2 h / 75 °C
View Scheme
参考文献
HANMI PHARM CO., LTD.; BAE, In Hwan; SON, Jung Beom; HAN, Sang Mi; KWAK, Eun Joo; KIM, Ho Seok; SONG, Ji Young; BYUN, Eun Young; JUN, Seung Ah; AHN, Young Gil; SUH, Kwee Hyun
Patent: WO2013/100632 A1, 2013 ;
反应条件
1: palladium(II) oxide hydrate; triethylamine; hydrogen / methanol / 5 h
2: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / benzene / 2 h / 75 °C
View Scheme
参考文献
HANMI PHARM CO., LTD.; BAE, In Hwan; SON, Jung Beom; HAN, Sang Mi; KWAK, Eun Joo; KIM, Ho Seok; SONG, Ji Young; BYUN, Eun Young; JUN, Seung Ah; AHN, Young Gil; SUH, Kwee Hyun
Patent: WO2013/100632 A1, 2013 ;
反应条件
1: 24 h / 200 °C
2: trichlorophosphate / N,N-dimethyl-formamide / 4 h / 110 °C
3: palladium(II) oxide hydrate; triethylamine; hydrogen / methanol / 5 h
4: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / benzene / 2 h / 75 °C
View Scheme
参考文献
HANMI PHARM CO., LTD.; BAE, In Hwan; SON, Jung Beom; HAN, Sang Mi; KWAK, Eun Joo; KIM, Ho Seok; SONG, Ji Young; BYUN, Eun Young; JUN, Seung Ah; AHN, Young Gil; SUH, Kwee Hyun
Patent: WO2013/100632 A1, 2013 ;
