4-(3-氯苯基)-4-羟基哌啶-1-羧酸叔丁酯合成路线 （共 3 条）
反应条件
1: 1-bromo-3-chlorobenzene With magnesium; iodine in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
2: tert-butyl 4-oxo-piperidine-1-carboxylate in tetrahydrofuran
T=20°C; Inert atmosphere;
3: With water; ammonium chloride in tetrahydrofuran
Saturated solution;
参考文献
Gruenenthal GmbH
Patent: US2009/264400 A1, 2009 ;
Location in patent: Page/Page column 97 ;
US 20090264400 A1
反应条件
1: in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
2: With ammonium chloride
参考文献
Almirall, S.A.; Vidal Juan, Bernat; Fernandez Collado, Juan Carlos; Erra Sola, Montserrat; Aguilar Izquierdo, Nuria; Mir Cepeda, Marta; Carranco Moruno, Inés
Patent: EP2489663 A1, 2012 ;
Location in patent: Paragraph 0102; 0103; 0104 ;
EP 2489663 A1
反应条件
1: m-ClC6H4Hal With magnesium in tetrahydrofuran
2: tert-butyl 4-oxo-piperidine-1-carboxylate in tetrahydrofuran
参考文献
Kumagai, Toshihito; Okubo, Taketoshi; Kataoka-Okubo, Hiromi; Chaki, Shigeyuki; Okuyama, Shigeru; Nakazato, Atsuro
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 5 p. 1357 - 1363
