1-Boc-4-氨基哌啶合成路线 （共 62 条）
反应条件
hydrogen; palladium 10 on activated carbon in ethanol P=5320.36 Torr;
参考文献
Kang, Jae-Hoon; Yu, Seung-Woo; Lee, Hee-Yeol; An, Kyung-Mi; Cho, Bong-Hwan
Patent: US2008/234333 A1, 2008 ;
Location in patent: Page/Page column 5 ;
反应条件
1: With hydroxylamine hydrochloride; sodium carbonate in water T=23°C; 14 h; 2: With hydrogen; Raney Ni in ethanol P=2585.81 Torr; 3.5 h; Solid phase;
参考文献
SmithKline Beecham Corporation
Patent: US6335340 B1, 2002 ;
Location in patent: Example 23 ;
反应条件
hydrogen; Raney nickel in ethanol P=2585.81 Torr;
参考文献
SCHERING CORPORATION
Patent: EP937069 B1, 2006 ;
Location in patent: Page/Page column 46-47 ;
反应条件
hydrogen; palladium(II) oxide hydrate in tetrahydrofuran; ethanol T=23°C; P=760.051 Torr; 6 h; Inert atmosphere;
参考文献
H. LUNDBECK A/S
Patent: US2011/92475 A1, 2011 ;
Location in patent: Page/Page column 17 ;
反应条件
1: in isobutyl methylketone T=0 - 20°C; 0.5 h; Inert atmosphereReflux; 2: With water in isopropyl alcohol T=50°C;
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Yan; HU, Yuandong; WANG, Huting; LIU, Yuliang; LI, Jijun; SUN, Deguang; WANG, Zhe; WEI, Yongheng; WANG, Zanping; TANG, Guojing; JING, Lutao
Patent: WO2012/103806 A1, 2012 ;
Location in patent: Page/Page column 33 ;
WO 2012/103806 A1
参考文献
Cabello-Sanchez, Noemi; Jean, Ludovic; Maddaluno, Jacques; Lasne, Marie-Claire; Rouden, Jacques
Journal of Organic Chemistry, 2007 , vol. 72, # 6 p. 2030 - 2039
反应条件
ammonium hydroxide; triphenylphosphine in 1,4-dioxane; methanol T=27 - 28°C; 0.5 h;
参考文献
Srivastava, Brijesh Kumar; Soni, Rina; Patel, Jayendra Z.; Solanki, Manish; Valani, Darshan; Gupta, Sunil; Mishra, Bhupendra; Takale, Vijay; Pandya, Purvi; Jain, Mukul R.; Patel, Pankaj R.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 18 p. 5227 - 5232
反应条件
ammonium hydroxide in methanol 2 h; Heating;
参考文献
Mach; Leudtke; Unsworth; Boundy; Nowak; Scripko; Elder; Jackson; Hoffman; Evora; Rao; Molinoff; Childers; Ehrenkaufer
Journal of Medicinal Chemistry, 1993 , vol. 36, # 23 p. 3707 - 3720
反应条件
sodium carbonate in tetrahydrofuran; water
反应条件
1: 4-amino-piperidine; benzaldehyde in toluene 3 h; Heating / reflux; 2: di-tert-butyl dicarbonate in toluene T=20°C;
参考文献
WO2008/58033 A2, ;
Page/Page column 38 ;
