1-Boc-4-氨基哌啶合成路线 （共 62 条）
反应条件
1: 94 percent / Et3N / CH2Cl2 / 12 h / 20 °C 2: H2 / Pd(OH)2/C / methanol / 12 h / 2585.81 Torr 3: CH2Cl2 / 6 h 4: 5.75 g / aq. NH3 / methanol / 6 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 25 p. 4404 - 4415
反应条件
1: H2 / Pd(OH)2/C / methanol / 12 h / 2585.81 Torr 2: CH2Cl2 / 6 h 3: 5.75 g / aq. NH3 / methanol / 6 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 25 p. 4404 - 4415
反应条件
in tetrahydrofuran; EtOH (abs); ethanol
反应条件
1: DIPEA / CH2Cl2 2: NaN3 / dimethylformamide / 20 °C 3: H2 / 10 percent Pd/C / methanol / 2068.59 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 18 p. 2475 - 2479
反应条件
1: CH2Cl2 / 6 h 2: 5.75 g / aq. NH3 / methanol / 6 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 25 p. 4404 - 4415
反应条件
1: DIPEA / CH2Cl2 2: NaN3 / dimethylformamide / 20 °C 3: H2 / 10 percent Pd/C / methanol / 2068.59 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 18 p. 2475 - 2479
反应条件
1: NaN3 / dimethylformamide / 20 °C 2: H2 / 10 percent Pd/C / methanol / 2068.59 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 18 p. 2475 - 2479
反应条件
1: Et3N / CH2Cl2 / 48 h / 20 °C 2: 160 mg / aq. AcOH / 48 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 72, # 6 p. 2030 - 2039
反应条件
1: Na2SO4 / CH2Cl2 / 24 h / 20 °C 2: Et3N / CH2Cl2 / 48 h / 20 °C 3: 160 mg / aq. AcOH / 48 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 72, # 6 p. 2030 - 2039
反应条件
1: sodium carbonate / |Reflux; |Inert atmosphere; |Dean-Stark 2: 0.5 h / 0 - 20 °C / |Inert atmosphere; |Dean-Stark 3: water / isopropyl alcohol / 50 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 9, # 1 p. 102 - 104
