1-Boc-4-氨基哌啶合成路线 （共 62 条）
反应条件
1: With triethylamine in isopropyl alcohol
T=0 - 40°C; 2.66667 h; Cooling with ice;
2: With hydrogenchloride; water in isopropyl alcohol
T=0 - 50°C; 1.5 h;
3: With sodium hydroxide in water; isopropyl alcohol
T=0°C; 0.666667 h;
参考文献
TAISHO PHARMACEUTICAL CO., LTD.; KANUMA, Kosuke; MIYAKOSHI, Naoki; KAWAMURA, Madoka; SHIBATA, Tsuyoshi
Patent: WO2010/38901 A1, 2010 ;
Location in patent: Page/Page column 76-77 ;
WO 2010/038901 A1
反应条件
in tetrahydrofuran
T=140°C; Microwave irradiation;
参考文献
Buckley, George M.; Ceska, Thomas A.; Fraser, Joanne L.; Gowers, Lewis; Groom, Colin R.; Higueruelo, Alicia Perez; Jenkins, Kerry; Mack, Stephen R.; Morgan, Trevor; Parry, David M.; Pitt, William R.; Rausch, Oliver; Richard, Marianna D.; Sabin, Verity
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 11 p. 3291 - 3295
