4-(2-硝基苄基氨基)哌啶-1-羧酸叔丁酯合成路线 （共 4 条）
反应条件
triethylamine in dichloromethane
16 h;
参考文献
Gutierrez, Corey; Termin, Andreas; Hadida-Ruah, Sara; Joshi, Pramod; Bergeron, Daniele; Yoo, Sanghee; Binch, Hayley; Come, Jon; Cao, Jingrong; Nanthakumar, Suganthi
Patent: US2008/4261 A1, 2008 ;
Location in patent: Page/Page column 138 ;
US 20080004261 A1
反应条件
1: 2-nitrobenzylamine hydrochloride With triethylamine in 1,2-dichloro-ethane
T=20°C; 0.0833333 h;
2: tert-butyl 4-oxo-piperidine-1-carboxylate With sodium tris(acetoxy)borohydride; acetic acid in 1,2-dichloro-ethane
T=20°C; 1 h;
3: With water; sodium carbonate in 1,2-dichloro-ethane
参考文献
NEUROGEN CORPORATION
Patent: WO2008/60568 A2, 2008 ;
Location in patent: Page/Page column 66 ;
WO 2008/060568 A2
反应条件
sodium tetrahydroborate
1) methanol, 20 deg C, 1 h; 2) 1 h; Yield given. Multistep reaction;
参考文献
Obase; Takai; Teranishi; Nakamizo
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 3 p. 565 - 573
反应条件
hydrogen; palladium on activated charcoal in ethanol
T=20°C; P=2585.7 Torr; 10 h;
参考文献
Obase; Takai; Teranishi; Nakamizo
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 3 p. 565 - 573
