3-溴-1-(2-氯苯基)-1H-吡唑-5-羧酸合成路线 （共 5 条）
反应条件
1: With methanol; sodium hydroxide; water
T=20°C; 2 h;
2: With hydrogenchloride in water
pH=2;
参考文献
E.I. DUPONT DE NEMOURS AND COMPANY
Patent: WO2005/118552 A2, 2005 ;
Location in patent: Page/Page column 13 ;
反应条件
1.1: hydrogenchloride / water / 0.33 h / 20 °C
2.1: N-bromosuccinmide / N,N-dimethyl-formamide / 0.5 h / 0 °C
3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C
4.1: potassium permanganate / acetone / 20 - 40 °C
5.1: sodium hydroxide / water; methanol / 2 h / 20 °C
5.2: pH 2
View Scheme
参考文献
E. I. du Pont de Nemours and Company; Lham, George Philip
Patent: EP2564706 A1, 2013 ;
反应条件
1.1: N-bromosuccinmide / N,N-dimethyl-formamide / 0.5 h / 0 °C
2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C
3.1: potassium permanganate / acetone / 20 - 40 °C
4.1: sodium hydroxide / water; methanol / 2 h / 20 °C
4.2: pH 2
View Scheme
参考文献
E. I. du Pont de Nemours and Company; Lham, George Philip
Patent: EP2564706 A1, 2013 ;
反应条件
1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C
2.1: potassium permanganate / acetone / 20 - 40 °C
3.1: sodium hydroxide / water; methanol / 2 h / 20 °C
3.2: pH 2
View Scheme
参考文献
E. I. du Pont de Nemours and Company; Lham, George Philip
Patent: EP2564706 A1, 2013 ;
反应条件
1.1: potassium permanganate / acetone / 20 - 40 °C
2.1: sodium hydroxide / water; methanol / 2 h / 20 °C
2.2: pH 2
View Scheme
参考文献
E. I. du Pont de Nemours and Company; Lham, George Philip
Patent: EP2564706 A1, 2013 ;
