2-氨基-5-氰基-3-甲基苯甲酸合成路线 （共 5 条）
反应条件
in N,N-dimethyl-formamide
T=140°C; 20 h; Inert atmosphere;
参考文献
Allendoerfer, Nadine; Es-Sayed, Mazen; Nieger, Martin; Braese, Stefan
Tetrahedron Letters, 2012 , vol. 53, # 4 p. 388 - 391
反应条件
1: With copper(l) iodide; potassium iodide in chlorobenzene
T=20°C;
2: With N-methyl-2-(methylamino)ethylamine in chlorobenzene
T=115°C; 18 h;
参考文献
E.I. DUPONT DE NEMOURS AND COMPANY
Patent: WO2006/68669 A1, 2006 ;
Location in patent: Page/Page column 18; 27 ;
反应条件
in DMF (N,N-dimethyl-formamide)
T=140 - 145°C; 20 h;
参考文献
E.I. DUPONT DE NEMOURS AND COMPANY
Patent: WO2005/118552 A2, 2005 ;
Location in patent: Page/Page column 13-14 ;
反应条件
copper(l) iodide; potassium iodide; N-methyl-2-(methylamino)ethylamine in chlorobenzene
T=120°C; 24 h;
参考文献
Selby, Thomas P.; Lahm, George P.; Stevenson, Thomas M.; Hughes, Kenneth A.; Cordova, Daniel; Annan, I. Billy; Barry, James D.; Benner, Eric A.; Currie, Martin J.; Pahutski, Thomas F.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 23 p. 6341 - 6345
反应条件
1: N-iodo-succinimide / N,N-dimethyl-formamide / 1 h / 75 °C / Inert atmosphere
2: N,N-dimethyl-formamide / 20 h / 140 °C / Inert atmosphere
View Scheme
参考文献
Allendoerfer, Nadine; Es-Sayed, Mazen; Nieger, Martin; Braese, Stefan
Tetrahedron Letters, 2012 , vol. 53, # 4 p. 388 - 391
