2,4-二氯-5-嘧啶甲醛合成路线 （共 4 条）
反应条件
1: 5-Bromo-2,4-dichloror-pyrimidine With isopropylmagnesium chloride lithium chloride complex in tetrahydrofuran T=78°C; 1 h; 2: (4-morpholinyl)methanone in tetrahydrofuran T=-78 - -35°C; 1.5 h; 3: With hydrogenchloride; water in tetrahydrofuran T=-35°C;
参考文献
ABBOTT LABORATORIES; WOLLER, Kevin R.; CURTIN, Michael L.; FRANK, Kristine E.; JOSEPHSOHN, Nathan S.; LI, Biqin C.; WISHART, Neil
Patent: WO2011/156698 A2, 2011 ;
Location in patent: Page/Page column 52 ;
WO 2011/156698 A2
反应条件
1: 5-Bromo-2,4-dichloror-pyrimidine With hydrogenchloride in tetrahydrofuran T=-78 - 35°C; 0.5 h; 2: N,N-dimethyl-formamide in tetrahydrofuran T=-78°C; 2 h;
参考文献
Ding, Qingjie; Jiang, Nan; Roberts, John Lawson
Patent: US2005/277655 A1, 2005 ;
Location in patent: Page/Page column 15 ;
反应条件
1: in tetrahydrofuran; diethyl ether T=-78°C; 2 h; 2: With hydrogenchloride in tetrahydrofuran; diethyl ether; water
参考文献
Ding, Qingjie; Jiang, Nan; Roberts, John Lawson
Patent: US2005/277655 A1, 2005 ;
Location in patent: Page/Page column 16 ;
反应条件
hydrazine in tetrahydrofuran T=20°C; 0.5 h;
参考文献
Ding, Qingjie; Jiang, Nan; Roberts, John Lawson
Patent: US2005/277655 A1, 2005 ;
Location in patent: Page/Page column 15 ;
