ammonia in water; ethyl acetate

1: With thionyl chloride in dichloromethane 6 h; Reflux; 2: With ammonia in water; ethyl acetate

1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -75 °C 1.2: -75 - 20 °C 1.3: pH 1 / Acidic conditions 2.1: thionyl chloride / dichloromethane / 6 h / Reflux 3.1: ammonium hydroxide / ethyl acetate View Scheme