triethylamine; aluminum oxide; ruthenium in acetonitrile T=90°C; Sonogashira coupling; 24 h;

1: 94 percent / Pd(PPh3)2Cl2; CuI; Et3N / 48 h / 20 °C 2: 95 percent / aq. NaOH / methanol; tetrahydrofuran / 24 h / 20 °C 3: Pd(PPh3)2Cl2; CuI / triethylamine View Scheme

1: 95 percent / aq. NaOH / methanol; tetrahydrofuran / 24 h / 20 °C 2: Pd(PPh3)2Cl2; CuI / triethylamine View Scheme

bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide in triethylamine Condensation; Sonogashira cross-coupling;