N-甲氧基-N-甲基-4-(喹啉-2-基甲氧基)-苯甲酰胺合成路线 （共 6 条）
反应条件
triethylamine in tetrahydrofuran
18 h;
参考文献
Pfizer Inc
Patent: US2006/154931 A1, 2006 ;
Location in patent: Page/Page column 24 ;
反应条件
1: potassium carbonate / acetone / 22 h / 60 °C / Inert atmosphere
2: water; sodium hydroxide / tetrahydrofuran; methanol; dichloromethane / 20 °C
3: thionyl chloride / chloroform / Inert atmosphere
4: triethylamine / dichloromethane
View Scheme
参考文献
Tu, Zhude; Fan, Jinda; Li, Shihong; Jones, Lynne A.; Cui, Jinquan; Padakanti, Prashanth K.; Xu, Jinbin; Zeng, Dexing; Shoghi, Kooresh I.; Perlmutter, Joel S.; MacH, Robert H.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 5 p. 1666 - 1673
反应条件
1: thionyl chloride / chloroform / Inert atmosphere
2: triethylamine / dichloromethane
View Scheme
参考文献
Tu, Zhude; Fan, Jinda; Li, Shihong; Jones, Lynne A.; Cui, Jinquan; Padakanti, Prashanth K.; Xu, Jinbin; Zeng, Dexing; Shoghi, Kooresh I.; Perlmutter, Joel S.; MacH, Robert H.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 5 p. 1666 - 1673
反应条件
1: water; sodium hydroxide / tetrahydrofuran; methanol; dichloromethane / 20 °C
2: thionyl chloride / chloroform / Inert atmosphere
3: triethylamine / dichloromethane
View Scheme
参考文献
Tu, Zhude; Fan, Jinda; Li, Shihong; Jones, Lynne A.; Cui, Jinquan; Padakanti, Prashanth K.; Xu, Jinbin; Zeng, Dexing; Shoghi, Kooresh I.; Perlmutter, Joel S.; MacH, Robert H.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 5 p. 1666 - 1673
反应条件
1: potassium carbonate / acetone / 22 h / 60 °C / Inert atmosphere
2: water; sodium hydroxide / tetrahydrofuran; methanol; dichloromethane / 20 °C
3: thionyl chloride / chloroform / Inert atmosphere
4: triethylamine / dichloromethane
View Scheme
参考文献
Tu, Zhude; Fan, Jinda; Li, Shihong; Jones, Lynne A.; Cui, Jinquan; Padakanti, Prashanth K.; Xu, Jinbin; Zeng, Dexing; Shoghi, Kooresh I.; Perlmutter, Joel S.; MacH, Robert H.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 5 p. 1666 - 1673
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran / Cooling with ice
1.2: -78 °C
2.1: 1 h / Reflux
3.1: hydrazine hydrate / methanol / 1 h / Reflux
4.1: sulfuric acid / ethanol / 1 h / Reflux
View Scheme
参考文献
Tu, Zhude; Fan, Jinda; Li, Shihong; Jones, Lynne A.; Cui, Jinquan; Padakanti, Prashanth K.; Xu, Jinbin; Zeng, Dexing; Shoghi, Kooresh I.; Perlmutter, Joel S.; MacH, Robert H.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 5 p. 1666 - 1673
