3,4-二氢-6-[4-[1-(反式-4-羟基环己基)-1H-四唑-5-基]丁氧基]-2(1H)-喹啉酮合成路线 （共 4 条）
反应条件
hydrogen; palladium on activated charcoal in methanol; acetic acid T=60 - 70°C; P=1140 - 1520 Torr; 8 h;
参考文献
Nishi; Tabusa; Tanaka; Shimizu; Nakagawa
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1140 - 1147
反应条件
1: 74 percent / aq.85percent KOH / propan-2-ol / 18 h / Heating 2: 93 percent / hydrogen / 10percent Pd-C / methanol; acetic acid / 8 h / 60 - 70 °C / 1140 - 1520 Torr View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 33, # 3 p. 1140 - 1147
反应条件
1: 74 percent / aq.85percent KOH / propan-2-ol / 18 h / Heating 2: 93 percent / hydrogen / 10percent Pd-C / methanol; acetic acid / 8 h / 60 - 70 °C / 1140 - 1520 Torr View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 33, # 3 p. 1140 - 1147
反应条件
metabolism studies, pharmacokinetic;
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 35, # 7 A p. 1133 - 1140
