1: 1-amino-2-fluoro-4-iodobenzene; 1,1'-carbonyldiimidazole With toluene-4-sulfonic acid 3-cyclopropyl-8-methyl-1-(3-nitrophenyl)-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl ester in DMF (N,N-dimethyl-formamide) T=0 - 20°C; 5 - 18 h; 2: anhydrous cyclopropylamine in DMF (N,N-dimethyl-formamide) T=0 - 20°C; 1 h; Product distribution / selectivity;

methanesulfonyl chloride in DMF (N,N-dimethyl-formamide) T=20°C; 4 h;