4-氯-1H-吡唑并[4,3-c]吡啶合成路线 （共 7 条）
反应条件
hydrazine hydrate in ethylene glycol dimethyl ether T=20 - 75°C;
参考文献
WO2010/106333 A1, ;
Page/Page column 78-79 ;
WO 2010/106333 A1
反应条件
hydrazine in ethanol T=20°C; 15 h;
参考文献
WO2012/66061 A1, ;
Page/Page column 77 ;
WO 2012/066061 A1
反应条件
trichlorophosphate T=110°C; 18 h;
参考文献
WO2005/121094 A1, ;
Page/Page column 52 ;
反应条件
trichlorophosphate 3 h; Heating / reflux;
参考文献
EP1772454 A1, ;
Page/Page column 63 ;
EP 1772454 A1
反应条件
1.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran / 3.5 h / -78 - 0 °C 1.2: 1.5 h / -78 °C 2.1: hydrazine hydrate / ethylene glycol dimethyl ether / 20 - 75 °C View Scheme
参考文献
WO2012/38743 A1, ;
WO 2012/038743 A1
反应条件
iodine; potassium hydroxide in 1,4-dioxane T=75°C; 4 h;
参考文献
MEDICAL RESEARCH COUNCIL TECHNOLOGY; GENENTECH INC.; CHAN, Bryan; CHEN, Huifen; ESTRADA, Anthony; SHORE, Daniel; SWEENEY, Zachary; McIVER, Edward
Patent: WO2012/38743 A1, 2012 ;
Location in patent: Page/Page column 82 ;
WO 2012/038743 A1
反应条件
N-bromosuccinmide in acetonitrile 3 h; Reflux;
参考文献
MEDICAL RESEARCH COUNCIL TECHNOLOGY; MCIVER, Edward, Giles; SMILJANIC, Ela; HARDING, Denise, Jamilla; HOUGH, Joanne
Patent: WO2010/106333 A1, 2010 ;
Location in patent: Page/Page column 80 ;
WO 2010/106333 A1
