3-(4-甲基苯基)-1,2,3,4-四氢-6,7-异喹啉二醇氢溴酸盐(1:1)合成路线 （共 5 条）
反应条件
hydrogen bromide
T=100°C; 6.5 h;
参考文献
Valenta; Holubek; Svatek; et al.
Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # 5 p. 1447 - 1464
反应条件
1: 72 percent / AlCl3 / 1.) 15 deg C, 6.5 h, 2.) R.T. overnight
2: 98 percent formic acid / 12 h / 170 - 180 °C
3: 66 percent / POCl3 / toluene / 4.5 h / Heating
4: 1.) NaBH4, 5M NaOH, 2.) HCl / 1.) ethanol, reflux, 6 h, 2.) ether.
5: 95 percent / 46 percent hydrobromic acid / 6.5 h / 100 °C
View Scheme
参考文献
Valenta; Holubek; Svatek; et al.
Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # 5 p. 1447 - 1464
反应条件
1: 66 percent / POCl3 / toluene / 4.5 h / Heating
2: 1.) NaBH4, 5M NaOH, 2.) HCl / 1.) ethanol, reflux, 6 h, 2.) ether.
3: 95 percent / 46 percent hydrobromic acid / 6.5 h / 100 °C
View Scheme
参考文献
Valenta; Holubek; Svatek; et al.
Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # 5 p. 1447 - 1464
反应条件
1: 72 percent / AlCl3 / 1.) 15 deg C, 6.5 h, 2.) R.T. overnight
2: 98 percent formic acid / 12 h / 170 - 180 °C
3: 66 percent / POCl3 / toluene / 4.5 h / Heating
4: 1.) NaBH4, 5M NaOH, 2.) HCl / 1.) ethanol, reflux, 6 h, 2.) ether.
5: 95 percent / 46 percent hydrobromic acid / 6.5 h / 100 °C
View Scheme
参考文献
Valenta; Holubek; Svatek; et al.
Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # 5 p. 1447 - 1464
反应条件
1: 1.) NaBH4, 5M NaOH, 2.) HCl / 1.) ethanol, reflux, 6 h, 2.) ether.
2: 95 percent / 46 percent hydrobromic acid / 6.5 h / 100 °C
View Scheme
参考文献
Valenta; Holubek; Svatek; et al.
Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # 5 p. 1447 - 1464
