4-(2-溴-乙氧基)-3-氟苯甲腈合成路线 （共 3 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=60°C; Inert atmosphere;
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Li; HU, Yuandong; YU, Rong; HU, Wei; ZHAO, Na; PENG, Yong; LUO, Hong; HAN, Yongxin
Patent: WO2013/97773 A1, 2013 ;
Location in patent: Paragraph 0160; 0278 ;
反应条件
1: boron tribromide / dichloromethane / 72 h / 0 °C / |Inert atmosphere; |Reflux
2: potassium carbonate / N,N-dimethyl-formamide / 60 °C / |Inert atmosphere
View Scheme
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Li; HU, Yuandong; YU, Rong; HU, Wei; ZHAO, Na; PENG, Yong; LUO, Hong; HAN, Yongxin
Patent: WO2013/97773 A1, 2013 ;
反应条件
1: N,N-dimethyl-formamide / 120 °C
2: boron tribromide / dichloromethane / 72 h / 0 °C / |Inert atmosphere; |Reflux
3: potassium carbonate / N,N-dimethyl-formamide / 60 °C / |Inert atmosphere
View Scheme
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Li; HU, Yuandong; YU, Rong; HU, Wei; ZHAO, Na; PENG, Yong; LUO, Hong; HAN, Yongxin
Patent: WO2013/97773 A1, 2013 ;
