1-(6-氯吡啶-3-基)-1-丙酮合成路线 （共 3 条）
反应条件
bis[2-(N,N-dimethylamino)ethyl] ether in tetrahydrofuran
T=-60°C; Grignard reaction; 0.05 h;
参考文献
Wang, Xiao-Jun; Zhang, Li; Sun, Xiufeng; Xu, Yibo; Krishnamurthy, Dhileepkumar; Senanayake, Chris H.
Organic Letters, 2005 , vol. 7, # 25 p. 5593 - 5595
反应条件
1: in tetrahydrofuran; diethyl ether
T=25°C; 18 h; Heating / reflux;
2: With ammonium chloride in tetrahydrofuran; diethyl ether; water
参考文献
Brewster, William Kirkland; Klittich, Carla Jean Rasmussen; Balko, Terry William; Breaux, Nneka Tuere; Erickson, William Randal; Hunter, James Edward; Lowe, Christian Thomas; Ricks, Michael John; Siddall, Thomas Lyman; Yerkes, Carla Nanette; Zhu, Yuanming
Patent: US2006/89370 A1, 2006 ;
Location in patent: Page/Page column 35 ;
反应条件
in tetrahydrofuran
T=-78°C; Grignard reaction;
参考文献
Wang, Xiao-Jun; Zhang, Li; Sun, Xiufeng; Xu, Yibo; Krishnamurthy, Dhileepkumar; Senanayake, Chris H.
Organic Letters, 2005 , vol. 7, # 25 p. 5593 - 5595
