3-氨基-2-吲哚羧酸乙酯合成路线 （共 13 条）
反应条件
trifluoroacetic acid in tetrahydrofuran; water; acetonitrile
参考文献
Alkan, Sefik S.; Dinerstein, Robert J.; Hrib, Nicholas J.; Subramaniam, Arun; Jurcak, John G.
Patent: US2004/6123 A1, 2004 ;
反应条件
1: 53 percent / NaHCO3 / ethanol / 42 h / Heating 2: 50 percent / t-BuOK / tetrahydrofuran / 2 h View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 20, p. 495 - 499
反应条件
hydrogenchloride in ethanol 8 h; Heating;
参考文献
Archiv der Pharmazie, , vol. 325, # 7 p. 439 - 452
反应条件
hydrazine hydrate 4 h; Heating;
参考文献
Monge; Aldana; Font; Arraras; Santiago; Lopez-Unzu; Martinez de Irujo; Alberdi
Archiv der Pharmazie, 1992 , vol. 325, # 7 p. 439 - 452
反应条件
1: 79 percent / hydrazine hydrate / 4 h / Heating 2: 80 percent / ethanol / 0.17 h / Heating 3: 83 percent / conc. HCl, aq. NaNO2 / H2O / 5 h / Ambient temperature 4: 60 percent / hydrazine hydrate / ethanol / 5 h / Heating View Scheme
参考文献
Fernandez-Alvarez Monge; Aldane; Arraras
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 3 p. 557 - 560
反应条件
1: 79 percent / hydrazine hydrate / 4 h / Heating 2: 78 percent / ethanol / 0.17 h / Heating 3: 84 percent / conc. HCl, aq. NaNO2 / H2O / 5 h / Ambient temperature View Scheme
参考文献
Fernandez-Alvarez Monge; Aldane; Arraras
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 3 p. 557 - 560
反应条件
1: 42 percent / NaHCO3 / CHCl3; H2O / 2 h / Ambient temperature 2: 60 percent / 98percent N2H4*H2O / CHCl3 / 2 h / Ambient temperature 3: 98 percent / KOH / ethanol / 2 h / Heating 4: 50 percent / 37percent aq. HCl / 0.5 h 5: 41 percent / Heating View Scheme
参考文献
Santagati; Longmore; Guccione; Langer; Tonnel; Modica; Monsu Scolaro; Russo
European Journal of Medicinal Chemistry, 1997 , vol. 32, # 12 p. 973 - 985
参考文献
Russo; Guccione; Santagati; Caruso; Leone; Attaguile; Roxas
Farmaco, Edizione Scientifica, 1988 , vol. 43, # 5 p. 409 - 420
参考文献
Russo; Guccione; Santagati; Caruso; Leone; Attaguile; Roxas
Farmaco, Edizione Scientifica, 1988 , vol. 43, # 5 p. 409 - 420
反应条件
1: 29 percent / 0.25 h / 180 - 190 °C
2: NaH / dimethylformamide / 17 h
View Scheme
参考文献
Unangst, Paul C.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 495 - 499
