6-氯-2-甲基-1H-吡咯并[2,3-b]吡啶合成路线 (共 2 条)
反应条件
methanol; sodium hydroxide; water
T=20°C;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2007/68418 A1, 2007 ;
Location in patent: Page/Page column 60 ;
WO 2007/068418 A1
反应条件
1: 6-chloro-2-methyl-1H-pyrrolo[2,3-b]pyridine With AlCl3, aluminium chloride in dichloromethane
T=20°C; 1 h;
2: chloroglyoxylic acid methyl ester in dichloromethane
T=20°C;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/123731 A2, 2005 ;
Location in patent: Page/Page column 65 ;
WO 2005/123731 A2