(S)-(+)-蒎烷二醇(二氯甲基)硼酸酯合成路线 （共 3 条）
反应条件
n-butyllithium in diethyl ether
T=20°C; 1.5 h;
参考文献
Millennium Pharmaceuticals, Inc.
Patent: US2011/245203 A1, 2011 ;
Location in patent: Page/Page column 28 ;
US 20110245203 A1
反应条件
1: boric acid trimethyl ester; dichloromethane With n-butyllithium in tetrahydrofuran
T=-78°C; 0.75 h; Inert atmosphere;
2: (1S,2S,3R,5S)-(+)-Pinanediol in tetrahydrofuran
T=20°C;
参考文献
Stein, Martin L.; Cui, Haissi; Beck, Philipp; Dubiella, Christian; Voss, Constantin; Krueger, Achim; Schmidt, Boris; Groll, Michael
Angewandte Chemie - International Edition, 2014 , vol. 53, # 6 p. 1679 - 1683
Angew. Chem., 2014 , vol. 126, # 6 p. 1705 - 1709,5
参考文献
Purandare, Ashok V.; Wan, Honghe; Laing, Naomi; Benbatoul, Khalid; Vaccaro, Wayne; Poss, Michael A.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 18 p. 4701 - 4704
