2-溴-N-甲基-3-氨基吡啶合成路线 （共 3 条）
反应条件
1: 3-amino-2-bromo-pyridine With lithium diisopropyl amide in tetrahydrofuran
T=0°C; 1 h;
2: methyl iodide in tetrahydrofuran
T=-78 - 20°C;
参考文献
Abbiati, Giorgio; Beccalli, Egle M.; Broggini, Gianluigi; Paladino, Giuseppe; Rossi, Elisabetta
Synthesis, 2005 , # 17 art. no. Z07705SS, p. 2881 - 2886
反应条件
trifluoroacetic acid in dichloromethane
T=0 - 25°C; 2 h;
参考文献
Lach, Franck; Koza, Patrice
ACS Combinatorial Science, 2012 , vol. 14, # 9 p. 491 - 495
反应条件
1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / 0 - 5 °C
2: trifluoroacetic acid / dichloromethane / 2 h / 0 - 25 °C
View Scheme
参考文献
Lach, Franck; Koza, Patrice
ACS Combinatorial Science, 2012 , vol. 14, # 9 p. 491 - 495
