2-氨基-5-碘-4-(三氟甲基)苯甲酸甲酯合成路线 （共 3 条）
反应条件
iodine; silver sulphate in ethanol
T=20°C; 2 h; Product distribution / selectivity;
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/2342 A1, 2006 ;
Location in patent: Page/Page column 56 ;
反应条件
1: sulfuric acid / 20 - 65 °C
2: silver sulphate; iodine / methanol / 20 °C
View Scheme
参考文献
NOVARTIS AG; BALA, Kamlesh, Jagdis; BUDD, Emma; EDWARDS, Lee; HOWSHAM, Catherine; LEGRAND, Darren, Mark; TAYLOR, Roger, John
Patent: WO2013/38390 A1, 2013 ;
反应条件
cesium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in 1,4-dioxane
T=20 - 80°C; 3 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/2342 A1, 2006 ;
Location in patent: Page/Page column 56-57 ;
