(E)-(-)-八氢环戊二烯并[b]吡咯-2-甲酸盐酸盐合成路线 （共 4 条）
反应条件
triethylamine in dichloromethane T=20°C;
参考文献
INSTYTUT FARMACEUTYCZNY
Patent: WO2005/108366 A1, 2005 ;
Location in patent: Page/Page column 12 ;
反应条件
1: 2,3,3a,4,5,6-hexahydrocyclopenta[b]pyrrole-2-carboxylic acid; (S,S,S)-2-azabicyclolt;3.3.0gt;octane-3-carboxylic acid hydrochloride With sodium hydroxide; hydrogenation catalyst in water T=20 - 25°C; pH=10 - 11; 2: N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride in water T=20 - 25°C; pH=10 - 11; 3 - 4 h; 3: With hydrogenchloride in water T=15 - 20°C; pH=4.4 - 5.2; 2.5 - 2.75 h; Product distribution / selectivity;
参考文献
sanofi-aventis Deutschland GmbH
Patent: US2009/17509 A1, 2009 ;
Location in patent: Page/Page column 7 ;
反应条件
in acetone T=0 - 50°C; 4 h; Electrodialysis; Product distribution / selectivity;
参考文献
Martens, Juergen; Luebben, Stefan
Journal fuer Praktische Chemie (Leipzig), 1990 , vol. 332, # 6 p. 1111 - 1117
反应条件
triethylamine in dichloromethane T=20°C;
参考文献
INSTYTUT FARMACEUTYCZNY
Patent: WO2005/108366 A1, 2005 ;
Location in patent: Page/Page column 12 ;
