4-溴-6-甲氧基喹啉-3-羧酸合成路线 （共 5 条）
反应条件
1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C 1.2: 2 h / 0 °C 2.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C View Scheme
参考文献
VITAS PHARMA RESEARCH PVT LTD; ALAPATI, Chandrasekhar; BANERJEE, Ankita; RANGARAJAN, Radha; KUMAR, Rajinder
Patent: WO2014/57415 A2, 2014 ;
反应条件
1: With sodium hydroxide; water in tetrahydrofuran
24 h;
2: With hydrogenchloride in tetrahydrofuran; water
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/14580 A1, 2006 ;
Location in patent: Page/Page column 38-39 ;
反应条件
1: ethanol / 4 h / 85 °C
2: Dowtherm™ A / 3 h / 250 °C
3: phosphorus tribromide / N,N-dimethyl-formamide / 1 h / 20 °C
4: sodium hydroxide / tetrahydrofuran / 0 - 20 °C
View Scheme
参考文献
VITAS PHARMA RESEARCH PVT LTD; ALAPATI, Chandrasekhar; BANERJEE, Ankita; RANGARAJAN, Radha; KUMAR, Rajinder
Patent: WO2014/57415 A2, 2014 ;
反应条件
1: Dowtherm™ A / 3 h / 250 °C
2: phosphorus tribromide / N,N-dimethyl-formamide / 1 h / 20 °C
3: sodium hydroxide / tetrahydrofuran / 0 - 20 °C
View Scheme
参考文献
VITAS PHARMA RESEARCH PVT LTD; ALAPATI, Chandrasekhar; BANERJEE, Ankita; RANGARAJAN, Radha; KUMAR, Rajinder
Patent: WO2014/57415 A2, 2014 ;
反应条件
1: phosphorus tribromide / N,N-dimethyl-formamide / 1 h / 20 °C
2: sodium hydroxide / tetrahydrofuran / 0 - 20 °C
View Scheme
参考文献
VITAS PHARMA RESEARCH PVT LTD; ALAPATI, Chandrasekhar; BANERJEE, Ankita; RANGARAJAN, Radha; KUMAR, Rajinder
Patent: WO2014/57415 A2, 2014 ;
