tris(tetra-n-butylammonium)hydrogen diphosphate in acetonitrile T=20°C;

1: 50 percent / lithium diisopropyl amide; potassium tert-butoxide / tetrahydrofuran / 2 h / -50 °C 2: 92 percent / 4-(N,N-dimethylamino)pyridine / CH2Cl2 / 2 h 3: 43 percent / tris(tetra-n-butylammonium) hydrogen pyrophosphate / acetonitrile / 20 °C View Scheme

1: 92 percent / 4-(N,N-dimethylamino)pyridine / CH2Cl2 / 2 h 2: 43 percent / tris(tetra-n-butylammonium) hydrogen pyrophosphate / acetonitrile / 20 °C View Scheme