N-[[2-[[[4-(氨基亚氨基甲基)苯基]氨基]甲基]-1-甲基-1H-苯并咪唑-5-基]羰基]-N-2-吡啶基-beta-丙氨酸乙酯 4-甲基苯磺酸盐合成路线 (共 2 条)
反应条件
1: potassium carbonate / water; acetone / 15 °C 2: ethyl acetate; ethanol / 8 h / 25 - 35 °C View Scheme
参考文献
MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; NAGARAJU, Chakilam; THIRUMALAI RAJAN, Srinivasan; ESWARAIAH, Sajja; KODANDA RAMPRASAD, Achampeta; RAGHURAM, Suraparaju
Patent: WO2012/77136 A2, 2012 ;
反应条件
1: 1-methyl-2-[N-[4-(1,2,4-oxadiazol-5-one-3-yl)phenyl]-amino-methyl]-benzimidazol-5-yl-carboxylic acid N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide With hydrogen; 10 palladium on activated carbon in ethanol; acetic acid
T=20°C; P=1500.15 Torr;
2: toluene-4-sulfonic acid in ethanol
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2007/71742 A1, 2007 ;
Location in patent: Page/Page column 25 ;