1,4-二苯基哌啶-4-甲腈合成路线 （共 3 条）
反应条件
sodium hydroxide; tri-n-butylhexadecylphosphonium bromide in water
T=100°C; 1 h;
参考文献
Thompson, Doug; Reeves, Perry C.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 771 - 772
反应条件
tris-(o-tolyl)phosphine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0) in toluene
20 h; Heating / reflux;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2006/18284 A1, 2006 ;
Location in patent: Page/Page column 47 ;
WO 2006/018284 A1
反应条件
N-ethyl-N,N-diisopropylamine in ethyl acetate
T=-30 - 20°C; 3 h;
参考文献
Asano, Shigehiro; Ban, Hitoshi
Heterocycles, 2008 , vol. 75, # 1 p. 183 - 188
