anhydrous tetramethylammonium chloride; trichlorophosphate T=140°C; 21 h;

1: t-BuOK / 1-methyl-pyrrolidin-2-one; tetrahydrofuran / 3 h / 100 °C 2: POCl3; Me4NCl / 21 h / 140 °C View Scheme

1.1: t-BuONa; NaH / tetrahydrofuran / 20 - 25 °C 1.2: tetrahydrofuran / 23 °C 2.1: p-toluenesulfonic acid monohydrate / toluene / 20 h / 117 °C 3.1: t-BuOK / 1-methyl-pyrrolidin-2-one; tetrahydrofuran / 3 h / 100 °C 4.1: POCl3; Me4NCl / 21 h / 140 °C View Scheme

anhydrous tetramethylammonium chloride; trichlorophosphate T=140°C;

potassium phosphate; 1,3-bis(2,4,6-trimethylphenyl)imidazolinium chloride; palladium diacetate in N,N-dimethyl-formamide T=50 - 80°C; Suzuki-Miyaura reaction; 13.5 h;