1: With trimethylsilyl trifluoromethanesulfonate; benzo[1,3,2]dioxaborole; [Rh(acac)(COD)]2; (R)-1-(2-phenylquinazolin-4-yl)-2-(Ph2P)-naphthalene in tetrahydrofuran T=25°C; Addition; Hydroboration; 2 h; 2: With sodium hydroxide; dihydrogen peroxide in tetrahydrofuran T=20°C; Oxidation; Hydrolysis; 1 h; Further stages. Title compound not separated from byproducts.;
1: With (S)-2-methyl-quinazolinap rhodium; benzo[1,3,2]dioxaborole in tetrahydrofuran T=0°C; 2 h; 2: With sodium hydroxide; dihydrogen peroxide in tetrahydrofuran; ethanol T=0 - 20°C; Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 69, # 20 p. 6572 - 6589
Oxonereg;; potassium carbonate; acetic acid; chiral 1a-methyl-3-fluoro-3-methyldecal-2-one in ethylene glycol dimethyl ether; water T=25°C; pH=8.5 - 9; 6 h; Title compound not separated from byproducts;
