反应条件
1: 1.) CuBr*SMe2, 2.) TMSCl / 1.) ether, -20 deg C, 15 min, 2.) ether, THF, -78 deg C, 1 h
2: 62 percent / triethylammonium fluoride / tetrahydrofuran / 120 h / Ambient temperature
3: 80 percent / NaIO4, RuCl3 / acetonitrile; CCl4; H2O / 1.5 h
4: 1.) N-methylmorpholine, isobutyl chloroformate, 2.) N-hydroxy-2-thiopyridone, Et3N, 3.) t-butyl thiol
5: 87 percent / aq. LiOH / tetrahydrofuran / 1.5 h
6: 74 percent / 6M HCl / 3 h / Heating
View Scheme
参考文献
Herdeis, C.; Hubmann, H. P.
Tetrahedron: Asymmetry, 1992 , vol. 3, # 9 p. 1213 - 1221
